Giant functional parathyroid carcinoma: a case report and literature review

Jian Wu; Yifang Sun; Qian Zhang; Ying Lin; Pengzhen Wang; Lei Leng; Lei Cao; Feng Yu; Haiyan Deng

doi:10.3389/fonc.2023.1310290

Giant functional parathyroid carcinoma: a case report and literature review

Front Oncol. 2024 Jan 5:13:1310290. doi: 10.3389/fonc.2023.1310290. eCollection 2023.

Authors

Jian Wu^#¹, Yifang Sun^#², Qian Zhang¹, Ying Lin¹, Pengzhen Wang³, Lei Leng⁴, Lei Cao¹, Feng Yu¹, Haiyan Deng¹

Affiliations

¹ Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
² Department of Ophthalmology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
³ Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.
⁴ Guangzhou Institute of Pathology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, China.

^# Contributed equally.

Abstract

Background: Parathyroid carcinoma is an infrequent neoplasm of the endocrine system, constituting roughly 0.5% to 5% of cases of primary hyperparathyroidism. The diagnosis of this condition presents a unique challenge for healthcare professionals.

Case report: We present a case of a 77-year-old female patient who presented with a longstanding right-sided neck tumor. The Positron emission tomography-computed tomography (PET-CT) scan detected a substantial tumor situated at the inferior border of the thyroid gland. A surgical procedure was conducted, resulting in the total excision of the tumor. The diagnosis of parathyroid carcinoma was confirmed through pathological investigation. At the six-month follow-up, the patient exhibited favorable post-operative outcomes with no evidence of recurrence.

Conclusion: The primary approaches for managing parathyroid carcinoma involve precise diagnosis and surgical removal. This case report provides confirmation that the implementation of rigorous treatment measures can yield a substantial improvement in the prognosis.

Keywords: diagnosis; parathyroid carcinoma; prognosis; rare endocrine tumors; treatment.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The present study received support from various funding sources, including the Guangzhou Science and Technology Foundation (Grant No. 202201020067), the Guangzhou Health Science and Technology Foundation (Grant No. 20221A010018), the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine Foundation (Grant No. 20241228), and the Basic and Applied Basic Foundation of Guangzhou Municipal Health Commission (Grant No. SL2024A03J00888).