Amount of Gleason Pattern 3 Is Not Predictive of Risk in Grade Group 2-4 Prostate Cancer

Andrew J Vickers; Melissa Assel; Matthew R Cooperberg; Samson W Fine; Scott Eggener

doi:10.1016/j.eururo.2024.01.005

Amount of Gleason Pattern 3 Is Not Predictive of Risk in Grade Group 2-4 Prostate Cancer

Eur Urol. 2024 Jul;86(1):1-3. doi: 10.1016/j.eururo.2024.01.005. Epub 2024 Jan 25.

Authors

Andrew J Vickers¹, Melissa Assel², Matthew R Cooperberg³, Samson W Fine⁴, Scott Eggener⁵

Affiliations

¹ Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: vickersa@mskcc.org.
² Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³ Departments of Urology and Epidemiology & Biostatistics, University of California San Francisco Comprehensive Cancer Center, San Francisco, CA, USA.
⁴ Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁵ Section of Urology, Department of Surgery, The University of Chicago Comprehensive Cancer Center, Chicago, IL, USA.

PMID: 38278665
DOI: 10.1016/j.eururo.2024.01.005

Abstract

We investigated whether total Gleason pattern 3 or the proportion of Gleason pattern 4 on biopsy is a significant predictor of adverse pathology. Our findings suggest that quantifying the amount rather than the proportion of Gleason pattern 4 would improve grade group assignment for decision-making in localized prostate cancer.

Publication types

Letter
Editorial

MeSH terms

Aged
Biopsy
Humans
Male
Middle Aged
Neoplasm Grading*
Predictive Value of Tests
Prostate / pathology
Prostatic Neoplasms* / pathology
Risk Assessment