Photo-sono activated BNT@MoS2 composites for rapid eradication of breast cancer

Rong Li; Hao Liu; Xiudong Guo; Xin Yang; Hailiang Zhang; Jianbo Song; Guannan Zhang

doi:10.1016/j.heliyon.2024.e25023

Photo-sono activated BNT@MoS₂ composites for rapid eradication of breast cancer

Heliyon. 2024 Jan 21;10(3):e25023. doi: 10.1016/j.heliyon.2024.e25023. eCollection 2024 Feb 15.

Authors

Rong Li^{1

2}, Hao Liu^{1

3}, Xiudong Guo¹, Xin Yang¹, Hailiang Zhang¹, Jianbo Song^{1

2}, Guannan Zhang^{1

2}

Affiliations

¹ Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
² Shanxi Provincial Key Laboratory for Translational Nuclear Medicine and Precision Protection, Taiyuan, 030006, China.
³ Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China.

Abstract

Non-invasive external energy triggered efficient tumor therapy is a promising specific treatment strategy. Herein, a composite material of bismuth sodium titanate (BNT) and molybdenum disulfide (MoS₂) with piezoelectric effect was designed for the synergistic treatment of breast cancer with near-infrared-II (NIR-II) light and ultrasound (US) activation. The BNT@MoS₂ exhibit excellent photothermal and acoustic properties upon excitation by 1060 nm NIR-II laser and US, respectively. The synergistic effect of hyperthermia and reactive oxygen species (ROS) under photoacoustic action endows the BNT@MoS₂ with remarkable anti-tumor activities, enabling them to eradicate breast cancer cells within 10 min. The work could provide new insights into the treatment of breast cancer.

Keywords: Biomaterials; Breast cancer; Composite materials; Photothermal therapy; Piezoelectric; Sono-dynamic therapy.