Rosa roxburghii Tratt juice inhibits NF-κB and increases IL-2 to alleviates the Foxp3-mediated Tregs imbalance in the peripheral blood of arseniasis patients

Qi Wang; Xiaolin Fang; Baofei Sun; Kai Zhu; Maolin Yao; Shaofeng Wei; Aihua Zhang

doi:10.1007/s10068-023-01384-0

Rosa roxburghii Tratt juice inhibits NF-κB and increases IL-2 to alleviates the Foxp3-mediated Tregs imbalance in the peripheral blood of arseniasis patients

Food Sci Biotechnol. 2023 Jul 24;33(4):935-944. doi: 10.1007/s10068-023-01384-0. eCollection 2024 Mar.

Authors

Qi Wang^#¹, Xiaolin Fang^#¹, Baofei Sun¹, Kai Zhu¹, Maolin Yao¹, Shaofeng Wei¹, Aihua Zhang¹

Affiliation

¹ The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, 550025 Guizhou People's Republic of China.

^# Contributed equally.

Abstract

Arsenic can cause immune inflammation, which is the basis of arsenic-induced damage to multiple organs and systems. Forkhead box P3 (Foxp3)-labelled CD4⁺CD25⁺ regulatory T cells (Tregs) play an essential role in maintaining immune homeostasis. Nuclear factor-κb (NF-κB) and Interleukin-2 (IL-2) are critical regulators of Foxp3. Rosa roxburghii Tratt (RRT) is an edible medicinal plant with anti-inflammation effects. In this study, a control group (n = 41) and an arseniasis group (n = 209) were recruited, and screened subjects from the arseniasis patients for RRTJ (n = 46) or placebo (n = 43) to explore the possible mechanism by which RRT alleviates immune inflammation. The results indicated that RRTJ can inhibits NF-κB and increases IL-2, and alleviates the Foxp3-mediated Tregs imbalance in the peripheral blood of arseniasis patients. In summary, these findings suggest a novel intervention or therapeutic target for immune inflammation in arseniasis patients and provide new evidence that RRTJ inhibits immune inflammation.

Supplementary information: The online version contains supplementary material available at 10.1007/s10068-023-01384-0.

Keywords: Arsenic; IL-2; Immune inflammation; NF-κB; Rosa roxburghii Tratt; Tregs imbalance.

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