One form and two functions: MBD of SETDB2 is a protein-interacting domain

Jujun Zhou; Taiping Chen; Xiaodong Cheng

doi:10.1016/j.str.2024.01.009

One form and two functions: MBD of SETDB2 is a protein-interacting domain

Structure. 2024 Mar 7;32(3):258-260. doi: 10.1016/j.str.2024.01.009.

Authors

Jujun Zhou¹, Taiping Chen¹, Xiaodong Cheng²

Affiliations

¹ Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
² Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: xcheng5@mdanderson.org.

PMID: 38458157
DOI: 10.1016/j.str.2024.01.009

Abstract

In this issue of Structure, Mahana et al.¹ present their structural characterization of an annotated methyl-CpG-binding domain (MBD) from the histone H3 lysine 9 methyltransferase SETDB2. This study reveals that, rather than binding DNA as previously hypothesized, this domain instead interacts with a cystine-rich domain from C11orf46, highlighting its involvement in protein-protein interactions.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

DNA / metabolism
DNA Methylation*
DNA-Binding Proteins* / chemistry
Methyltransferases / genetics

Substances

DNA-Binding Proteins
DNA
Methyltransferases

Abstract

Publication types

MeSH terms

Substances

Grants and funding