Targeting glycolysis to rescue 2-hydroxyglutarate immunosuppressive effects in dendritic cells and acute myeloid leukemia

Angela Maria Savino; Lucille Stuani

doi:10.3324/haematol.2023.284893

Targeting glycolysis to rescue 2-hydroxyglutarate immunosuppressive effects in dendritic cells and acute myeloid leukemia

Haematologica. 2024 Aug 1;109(8):2388-2390. doi: 10.3324/haematol.2023.284893.

Authors

Angela Maria Savino¹, Lucille Stuani²

Affiliations

¹ Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca.
² Institut de Recherche en Cancérologie de Montpellier (IRCM), Univ Montpellier, Institut régional du Cancer de Montpellier (ICM), INSERM U1194, Montpellier, France; Equipe Labellisée Ligue Contre le Cancer, Paris. lucille.stuani@inserm.fr.

No abstract available

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Dendritic Cells* / immunology
Dendritic Cells* / metabolism
Glutarates* / metabolism
Glycolysis* / drug effects
Humans
Leukemia, Myeloid, Acute* / drug therapy
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / immunology
Leukemia, Myeloid, Acute* / metabolism
Leukemia, Myeloid, Acute* / pathology
Mice

Substances

alpha-hydroxyglutarate
Glutarates

Grants and funding

Funding: AS is supported by a Rita Levi Montalcini career development award. LS is supported by the Association Laurette Fugain (number ALF 2021/11) and by the European Union’s Horizon 2020 Research and Innovation program under a Marie Skłodowska-Curie grant agreement (number 897140).