2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives

Xiaofeng Zhang; Miao Liu; Weiqi Qiu; Wei Zhang

doi:10.3390/molecules29061241

2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives

Molecules. 2024 Mar 11;29(6):1241. doi: 10.3390/molecules29061241.

Authors

Xiaofeng Zhang^{1

2}, Miao Liu^{1

3}, Weiqi Qiu^{1

4}, Wei Zhang¹

Affiliations

¹ Center for Green Chemistry and Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA.
² Department of Medicinal Chemistry, Cerevel Therapeutics, Cambridge, MA 02141, USA.
³ Department of Mechanical Engineering, University of Wisconsin Milwaukee, Milwaukee, WI 53211, USA.
⁴ Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 20467, USA.

Abstract

Quinoline is a privileged heterocyclic ring which can be found in many drug molecules and bioactive compounds. The development of synthetic methods for making quinoline derivatives continuously attracts the interest of organic and medicinal chemists. This paper highlights 2-azidobenzaldehyde-based [4+2] annulation for the synthesis of quinoline derivatives including fused and spiro-quinolines, quinoline-4-ols, 4-aminoquinolines, and related compounds.

Keywords: [4+2] annulation; azidobenzaldehyde; bioactive; heterocyclic; quinolines.

Publication types

Review

Grants and funding

This research received no external funding.