Synergistic inhibition of progesterone receptor-A/B signalling by simvastatin and mifepristone in human uterine leiomyomas

Clin Transl Med. 2024 Apr;14(4):e1672. doi: 10.1002/ctm2.1672.

Authors

Sadia Afrin¹, Gregory W Kirschen¹, Mariko Miyashita-Ishiwata¹, Malak El Sabeh², Mostafa A Borahay¹

Affiliations

¹ Department of Gynecology and Obstetrics, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
² Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Drug Synergism
Female
Humans
Leiomyoma* / drug therapy
Leiomyoma* / metabolism
Mifepristone* / pharmacology
Mifepristone* / therapeutic use
Receptors, Progesterone* / metabolism
Signal Transduction* / drug effects
Simvastatin* / pharmacology
Simvastatin* / therapeutic use
Uterine Neoplasms / drug therapy
Uterine Neoplasms / metabolism

Substances

Mifepristone
Simvastatin
Receptors, Progesterone

Grants and funding