Renal disease in pediatric rheumatology

Curr Opin Rheumatol. 2024 Sep 1;36(5):322-327. doi: 10.1097/BOR.0000000000001027. Epub 2024 May 16.

Abstract

Purpose of review: This review will provide updates in the outcomes in the common rheumatologic diseases with kidney involvement. Covered are also advances in therapeutics for the use of pediatric rheumatologic diseases with kidney involvement, as well as the potential kidney complications from other rheumatologic diseases and their medications.

Recent findings: Two of the more common rheumatologic diseases with kidney involvement, lupus and vasculitis, continue to show inadequate response to initial therapy of renal disease and practice continues to be driven by results of adult studies.

Summary: There is a continued need for pediatric specific studies in rheumatologic diseases with kidney involvement as outcomes continue to be inadequate. Despite recently approved treatments for adults with rheumatic diseases and kidney involvement, therapeutic options in pediatrics remain limited, contributing to the overall morbidity and mortality.

Publication types

  • Review

MeSH terms

  • Antirheumatic Agents / therapeutic use
  • Child
  • Humans
  • Kidney Diseases* / etiology
  • Kidney Diseases* / therapy
  • Rheumatic Diseases* / complications
  • Rheumatic Diseases* / therapy
  • Rheumatology / methods
  • Rheumatology / trends
  • Vasculitis / diagnosis
  • Vasculitis / etiology
  • Vasculitis / therapy

Substances

  • Antirheumatic Agents