IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status

Akshaya Keerthi Saikumar Jayalatha; Marlies E Ketelaar; Laura Hesse; Yusef E Badi; Nazanin Zounemat-Kermani; Sharon Brouwer; Nicole F Dijk; Maarten van den Berge; Victor Guryev; Ian Sayers; Judith E Vonk; Ian M Adcock; Gerard H Koppelman; Martijn C Nawijn

doi:10.1183/13993003.00005-2024

IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status

Eur Respir J. 2024 Jun 20;63(6):2400005. doi: 10.1183/13993003.00005-2024. Print 2024 Jun.

Authors

Akshaya Keerthi Saikumar Jayalatha^{1

2}, Marlies E Ketelaar^{1

3

2}, Laura Hesse^{1

2}, Yusef E Badi⁴, Nazanin Zounemat-Kermani⁴, Sharon Brouwer¹, Nicole F Dijk³, Maarten van den Berge⁵, Victor Guryev⁶, Ian Sayers⁷, Judith E Vonk⁸, Ian M Adcock⁴, Gerard H Koppelman³, Martijn C Nawijn⁹

Affiliations

¹ University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pathology and Medical Biology, Groningen, The Netherlands.
² Shared first authorship.
³ University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, The Netherlands.
⁴ National Heart and Lung Institute, Department of Respiratory Cell and Molecular Biology, Imperial College London, London, UK.
⁵ University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pulmonary Diseases, Groningen, The Netherlands.
⁶ University of Groningen, GRIAC Research Institute and European Research Institute for the Biology of Ageing, Groningen, The Netherlands.
⁷ Centre for Respiratory Research, NIHR Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
⁸ University of Groningen, University Medical Center Groningen, GRIAC Research institute, Department of Epidemiology, Groningen, The Netherlands.
⁹ University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Department of Pathology and Medical Biology, Groningen, The Netherlands m.c.nawijn@umcg.nl.

Abstract

IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. https://bit.ly/3WhuMbo

Publication types

Letter

MeSH terms

Asthma* / genetics
Asthma* / immunology
Asthma* / metabolism
Gene Expression Regulation
Haplotypes*
Humans
Interleukin-1 Receptor-Like 1 Protein* / genetics
Interleukin-1 Receptor-Like 1 Protein* / metabolism
Interleukin-33* / genetics
Interleukin-33* / metabolism
Interleukins / genetics
Interleukins / metabolism
Polymorphism, Single Nucleotide
Th2 Cells* / immunology

Substances

Interleukin-33
Interleukin-1 Receptor-Like 1 Protein
IL1RL1 protein, human
IL33 protein, human
Interleukins