Recent insights into N6-methyladenosine during viral infection

Abstract

The RNA modification of N⁶-methyladenosine (m⁶A) controls many aspects of RNA function that impact biological processes, including viral infection. In this review, we highlight recent work that shapes our current understanding of the diverse mechanisms by which m⁶A can regulate viral infection by acting on viral or cellular mRNA molecules. We focus on emerging concepts and understanding, including how viral infection alters the localization and function of m⁶A machinery proteins, how m⁶A regulates antiviral innate immunity, and the multiple roles of m⁶A in regulating specific viral infections. We also summarize the recent studies on m⁶A during SARS-CoV-2 infection, focusing on points of convergence and divergence. Ultimately, this review provides a snapshot of the latest research on m⁶A during viral infection.