Abstract
Among consecutive patients with multidrug-resistant Pseudomonas aeruginosa bacteremia or pneumonia we found those treated with ceftazidime-avibactam were more likely to develop resistance (defined as ≥4-fold increased MIC) than those treated with ceftolozane-tazobactam (40% vs 10%; P = .002). Ceftazidime-avibactam resistance was associated with new mutations in ampC and efflux regulatory pathways.
Keywords:
Pseudomonas; MDR; ceftazidime-avibactam; ceftolozane-tazobactam; resistance.
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Aged
-
Aged, 80 and over
-
Anti-Bacterial Agents* / pharmacology
-
Anti-Bacterial Agents* / therapeutic use
-
Azabicyclo Compounds* / pharmacology
-
Azabicyclo Compounds* / therapeutic use
-
Bacteremia* / drug therapy
-
Bacteremia* / microbiology
-
Bacterial Proteins / genetics
-
Ceftazidime* / pharmacology
-
Ceftazidime* / therapeutic use
-
Cephalosporins* / pharmacology
-
Cephalosporins* / therapeutic use
-
Drug Combinations
-
Drug Resistance, Multiple, Bacterial*
-
Female
-
Humans
-
Male
-
Microbial Sensitivity Tests
-
Middle Aged
-
Penicillanic Acid* / analogs & derivatives
-
Penicillanic Acid* / pharmacology
-
Penicillanic Acid* / therapeutic use
-
Pneumonia, Bacterial* / drug therapy
-
Pneumonia, Bacterial* / microbiology
-
Pseudomonas Infections* / drug therapy
-
Pseudomonas Infections* / microbiology
-
Pseudomonas aeruginosa* / drug effects
-
Pseudomonas aeruginosa* / genetics
-
Pseudomonas aeruginosa* / isolation & purification
-
Tazobactam
-
beta-Lactamases / genetics
Substances
-
Ceftazidime
-
Cephalosporins
-
Azabicyclo Compounds
-
avibactam, ceftazidime drug combination
-
Tazobactam
-
ceftolozane, tazobactam drug combination
-
Anti-Bacterial Agents
-
Drug Combinations
-
Penicillanic Acid
-
beta-Lactamases
-
Bacterial Proteins