Revised criteria for the diagnosis and staging of Alzheimer's disease

Clifford R Jack Jr; Scott J Andrews; Thomas G Beach; Teresa Buracchio; Billy Dunn; Ana Graf; Oskar Hansson; Carole Ho; William Jagust; Eric McDade; Jose Luis Molinuevo; Ozioma C Okonkwo; Luca Pani; Michael S Rafii; Philip Scheltens; Eric Siemers; Heather M Snyder; Reisa Sperling; Charlotte E Teunissen; Maria C Carrillo

doi:10.1038/s41591-024-02988-7

Revised criteria for the diagnosis and staging of Alzheimer's disease

Nat Med. 2024 Aug;30(8):2121-2124. doi: 10.1038/s41591-024-02988-7.

Authors

Clifford R Jack Jr¹, Scott J Andrews², Thomas G Beach³, Teresa Buracchio⁴, Billy Dunn⁵, Ana Graf⁶, Oskar Hansson^{7

8}, Carole Ho⁹, William Jagust¹⁰, Eric McDade¹¹, Jose Luis Molinuevo¹², Ozioma C Okonkwo¹³, Luca Pani¹⁴, Michael S Rafii¹⁵, Philip Scheltens¹⁶, Eric Siemers¹⁷, Heather M Snyder¹⁸, Reisa Sperling¹⁹, Charlotte E Teunissen²⁰, Maria C Carrillo¹⁸

Affiliations

¹ Department of Radiology, Mayo Clinic, Rochester, MN, USA. jack.clifford@mayo.edu.
² Global Evidence & Outcomes, Takeda Pharmaceuticals Company Limited, Cambridge, MA, USA.
³ Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.
⁴ Office of Neuroscience, US Food and Drug Administration, Silver Spring, MD, USA.
⁵ The Michael J Fox Foundation for Parkinson's Research, New York, NY, USA.
⁶ Neuroscience Global Drug Development, Novartis, Basel, Switzerland.
⁷ Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.
⁸ Memory Clinic, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
⁹ Denali Therapeutics, South San Francisco, CA, USA.
¹⁰ School of Public Health and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
¹¹ Department of Neurology, Washington University St Louis School of Medicine, St Louis, MO, USA.
¹² Experimental Medicine, Department Global Clinical Development H. Lundbeck A/S, Copenhagen, Denmark.
¹³ Department of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin School of Medicine, Madison, WI, USA.
¹⁴ University of Miami, Miami, FL, USA.
¹⁵ Alzheimer's Therapeutic Research Institute (ATRI), Keck School of Medicine at the University of Southern California, San Diego, CA, USA.
¹⁶ Department of Neurology, Amsterdam University Medical Center (Emeritus), Amsterdam, The Netherlands.
¹⁷ Clinical Research, Acumen Pharmaceuticals, Zionsville, IN, USA.
¹⁸ Medical & Scientific Relations Division, Alzheimer's Association, Chicago, IL, USA.
¹⁹ Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
²⁰ Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Amsterdam, The Netherlands.

Abstract

Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, prompting the revision of criteria for the diagnosis and staging of this disease.

Revised criteria for the diagnosis and staging of Alzheimer's disease

Authors

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Abstract

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Grants and funding