Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation

Erich J Sohn; David S Libich

doi:10.1016/j.str.2024.06.007

Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation

Structure. 2024 Jul 11;32(7):854-855. doi: 10.1016/j.str.2024.06.007.

Authors

Erich J Sohn¹, David S Libich²

Affiliations

¹ Greehey Children's Cancer Research Institute and Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
² Greehey Children's Cancer Research Institute and Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: libich@uthscsa.edu.

PMID: 38996511
DOI: 10.1016/j.str.2024.06.007

Abstract

In a recent issue of Nature Chemical Biology, Emmanouilidis et al. (2024) investigate the maturation of biomolecular condensates of FUS^1-267 and probe the molecular details of droplet aging. They observe that the liquid-to-solid transition of the droplet is mediated at the surface by FUS^1-267 molecules that have adopted β-strand conformations.

MeSH terms

Biomolecular Condensates / chemistry
Biomolecular Condensates / metabolism
Biophysics
Humans
Protein Conformation, beta-Strand
RNA-Binding Protein FUS* / chemistry
RNA-Binding Protein FUS* / metabolism

Substances

RNA-Binding Protein FUS

Grants and funding

R01 GM140127/GM/NIGMS NIH HHS/United States