Transcriptomics in the Study of Antiviral Innate Immunity

Methods Mol Biol. 2025:2854:83-91. doi: 10.1007/978-1-0716-4108-8_10.

Abstract

Transcriptomics is an extremely important area of molecular biology and is a powerful tool for studying all RNA molecules in an organism. Conventional transcriptomic technologies include microarrays and RNA sequencing, and the rapid development of single-cell sequencing and spatial transcriptomics in recent years has provided an enormous scope for research in this field. This chapter describes the application, significance, and experimental procedures of a variety of transcriptomic technologies in antiviral natural immunity.

Keywords: Antiviral innate immunity; Transcriptomics; Virus.

MeSH terms

  • Animals
  • Gene Expression Profiling* / methods
  • Humans
  • Immunity, Innate* / genetics
  • Oligonucleotide Array Sequence Analysis / methods
  • Sequence Analysis, RNA / methods
  • Single-Cell Analysis / methods
  • Transcriptome*
  • Virus Diseases / genetics
  • Virus Diseases / immunology