The promise of priming precursors: Advances in inducing CD4 binding site-directed HIV broadly neutralizing antibodies

Sci Immunol. 2024 Aug 30;9(98):eadq8862. doi: 10.1126/sciimmunol.adq8862. Epub 2024 Aug 30.

Abstract

HIV envelope immunogen designed to activate germline B cell precursors of CD4 binding site-specific neutralizing antibodies shows promise in monkeys.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • AIDS Vaccines / immunology
  • Animals
  • Antibodies, Neutralizing* / immunology
  • B-Lymphocytes / immunology
  • Binding Sites / immunology
  • Broadly Neutralizing Antibodies / immunology
  • CD4 Antigens* / immunology
  • CD4 Antigens* / metabolism
  • HIV Antibodies* / immunology
  • HIV Infections / immunology
  • HIV-1 / immunology
  • Humans

Substances

  • HIV Antibodies
  • Antibodies, Neutralizing
  • CD4 Antigens
  • AIDS Vaccines
  • Broadly Neutralizing Antibodies