Hantavirus: Preliminary assessment of lateral flow immune assay prototypes to detect IgM and IgG antibodies

Diagn Microbiol Infect Dis. 2024 Dec;110(4):116521. doi: 10.1016/j.diagmicrobio.2024.116521. Epub 2024 Sep 2.

Abstract

Three lateral flow immunoassay prototypes developed to detect IgM, IgG and IgM/IgG antibodies against Hantavirus were evaluated. A total of 163 samples were tested: 10 from Hantavirus patients, 103 from related diseases, and 50 from healthy controls. The prototypes exhibited 100 % sensitivity, 97.5 % to 99.3 % specificity, indicating promising improved diagnosis.

Keywords: Diagnostics; Hantavirus; Lateral flow assay; Rapid tests; Serology.

Publication types

  • Evaluation Study

MeSH terms

  • Antibodies, Viral* / blood
  • Hantavirus Infections* / diagnosis
  • Hantavirus Infections* / immunology
  • Humans
  • Immunoassay / methods
  • Immunoglobulin G* / blood
  • Immunoglobulin M* / blood
  • Orthohantavirus* / immunology
  • Sensitivity and Specificity*

Substances

  • Immunoglobulin M
  • Immunoglobulin G
  • Antibodies, Viral