Structure of the capsular antigen of Neisseria meningitidis serogroup K

Eur J Biochem. 1985 Nov 4;152(3):663-8. doi: 10.1111/j.1432-1033.1985.tb09246.x.

Abstract

The capsular antigen isolated from the culture liquid of a Neisseria meningitidis serogroup K(1811) fermentation consists of the 2-acetamido-2-deoxymannuronic acid disaccharide repeating unit as follows: ----3)-beta-D-ManpNAcA-(1----4)-beta-D-ManpNAcA-(1---- The polysaccharide is O-acetylated at the non-glycosylated C-4. Structural evidence has been obtained from sugar analysis, methylation analysis, as well as 1H and 13C NMR spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Bacterial*
  • Carbohydrates / analysis
  • Chemical Phenomena
  • Chemistry
  • Gas Chromatography-Mass Spectrometry
  • Hydrofluoric Acid
  • Magnetic Resonance Spectroscopy
  • Methylation
  • Neisseria meningitidis / classification
  • Neisseria meningitidis / immunology*
  • Oxidation-Reduction
  • Polysaccharides, Bacterial*
  • Serotyping

Substances

  • Antigens, Bacterial
  • Carbohydrates
  • Polysaccharides, Bacterial
  • Hydrofluoric Acid