Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria

Lvyuan Li; Yi Zhang; Qiling Tang; Chunyu Wu; Mei Yang; Yan Hu; Zhaojian Gong; Lei Shi; Can Guo; Zhaoyang Zeng; Pan Chen; Wei Xiong

doi:10.1007/s13402-024-01000-1

Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria

Cell Oncol (Dordr). 2024 Dec;47(6):2031-2047. doi: 10.1007/s13402-024-01000-1. Epub 2024 Oct 7.

Authors

Lvyuan Li^{1

2}, Yi Zhang^{1

2}, Qiling Tang^{1

2}, Chunyu Wu^{1

2}, Mei Yang^{1

2}, Yan Hu^{1

2}, Zhaojian Gong³, Lei Shi^{1

4}, Can Guo², Zhaoyang Zeng^{1

2}, Pan Chen^{5

6}, Wei Xiong^{7

8}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.
² Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, 410078, China.
³ Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410012, China.
⁴ Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
⁵ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China. chenpan08@csu.edu.cn.
⁶ Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, 410078, China. chenpan08@csu.edu.cn.
⁷ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China. xiongwei@csu.edu.cn.
⁸ Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, 410078, China. xiongwei@csu.edu.cn.

PMID: 39373857
DOI: 10.1007/s13402-024-01000-1

Abstract

Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been identified as a key factor influencing tumor immune responses. This review provides a comprehensive overview of the latest advancements in understanding the role of mitochondria in tumor immune surveillance, covering both innate and adaptive immune responses. Specifically, it outlines how mitochondria influence the function of the tumor immune system, underscoring their crucial role in modulating immune cell behavior to either promote or inhibit tumor development and progression. Additionally, this review highlights emerging drug interventions targeting mitochondria, including novel small molecules with significant potential in cancer therapy. Through an in-depth analysis, it explores how these innovative strategies could improve the efficacy and outlook of tumor treatment.

Keywords: Adaptive immune response; Immune surveillance; Innate immune response; Mitochondria; Tumor therapy.

Publication types

Review

MeSH terms

Animals
Humans
Immunologic Surveillance* / drug effects
Mitochondria* / drug effects
Mitochondria* / immunology
Mitochondria* / metabolism
Neoplasms* / drug therapy
Neoplasms* / immunology
Neoplasms* / pathology
Tumor Microenvironment / drug effects
Tumor Microenvironment / immunology

Abstract

Publication types

MeSH terms

Grants and funding