The Evolutionary Forest of Pancreatic Cancer

Cancer Discov. 2025 Feb 7;15(2):329-345. doi: 10.1158/2159-8290.CD-23-1541.

Abstract

Although the pancreatic cancer genome has been described, it has not been explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify the genomic features of PDAC in the context of evolutionary metrics and in doing so have identified a novel prognostic biomarker.

MeSH terms

  • Biomarkers, Tumor / genetics
  • Carcinoma, Pancreatic Ductal* / genetics
  • Carcinoma, Pancreatic Ductal* / pathology
  • Genomics / methods
  • Humans
  • Pancreatic Neoplasms* / genetics
  • Pancreatic Neoplasms* / pathology
  • Prognosis

Substances

  • Biomarkers, Tumor