Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma

Megan E Bischoff; Behrouz Shamsaei; Juechen Yang; Dina Secic; Bhargav Vemuri; Julie A Reisz; Angelo D'Alessandro; Caterina Bartolacci; Rafal Adamczak; Lucas Schmidt; Jiang Wang; Amelia Martines; Jahnavi Venkat; Vanina Toffessi Tcheuyap; Jacek Biesiada; Catherine A Behrmann; Katherine E Vest; James Brugarolas; Pier Paolo Scaglioni; David R Plas; Krushna C Patra; Shuchi Gulati; Julio A Landero Figueroa; Jarek Meller; John T Cunningham; Maria F Czyzyk-Krzeska

doi:10.1158/2159-8290.CD-24-0187

Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma

Cancer Discov. 2025 Feb 7;15(2):401-426. doi: 10.1158/2159-8290.CD-24-0187.

Authors

Megan E Bischoff^#¹, Behrouz Shamsaei^#^{2

3}, Juechen Yang^#^{2

3

4}, Dina Secic^#¹, Bhargav Vemuri², Julie A Reisz⁵, Angelo D'Alessandro⁵, Caterina Bartolacci⁶, Rafal Adamczak⁷, Lucas Schmidt⁸, Jiang Wang⁹, Amelia Martines¹, Jahnavi Venkat¹, Vanina Toffessi Tcheuyap^{10

11}, Jacek Biesiada^{3

4}, Catherine A Behrmann¹, Katherine E Vest¹², James Brugarolas^{10

11}, Pier Paolo Scaglioni⁶, David R Plas¹, Krushna C Patra¹, Shuchi Gulati^{6

13}, Julio A Landero Figueroa⁸, Jarek Meller^{2

3

4

7

14}, John T Cunningham¹, Maria F Czyzyk-Krzeska^{1

15

16}

Affiliations

¹ Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
² Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.
³ Division of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁴ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁵ Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado.
⁶ Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁷ Institute of Engineering and Technology, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Torun, Poland.
⁸ Trace Elements Group, Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York.
⁹ Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
¹⁰ Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
¹¹ Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
¹² Department of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.
¹³ Division of Oncology and Hematology, Department of Internal Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, California.
¹⁴ Department of Computer Science, University of Cincinnati College of Engineering and Applied Sciences, Cincinnati, Ohio.
¹⁵ Department of Veterans Affairs, Veteran Affairs Medical Center, Cincinnati, Ohio.
¹⁶ Department of Pharmacology and System Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

^# Contributed equally.

Abstract

The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.

MeSH terms

Animals
Carcinoma, Renal Cell* / metabolism
Carcinoma, Renal Cell* / pathology
Copper* / metabolism
Disease Progression
Humans
Kidney Neoplasms* / metabolism
Kidney Neoplasms* / pathology
Mice

Substances

Copper

Abstract

MeSH terms

Substances

Grants and funding