Pharmacotherapy for Anxiety Disorders

Psychiatr Clin North Am. 2024 Dec;47(4):689-709. doi: 10.1016/j.psc.2024.04.012. Epub 2024 Jun 10.

Abstract

Anxiety disorders are the most common psychiatric illness and include disorders such as generalized anxiety disorder (GAD), panic disorder (PD), and social anxiety disorder (SAD). Psychotherapy and pharmacotherapy are both effective treatments for anxiety disorders, with efficacy between 60% and 85%. Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors are first-line pharmacologic treatment for GAD, PD, and SAD. Recommendations for treating pediatric and geriatric populations vary slightly, but first-line treatments remain the same. Recent advancements in the treatment of anxiety disorders are limited although research has discovered novel pathways, which may lead to additional treatment options in the future.

Keywords: Anxiety; Generalized anxiety disorder; Pharmacotherapy; Selective serotonin reuptake inhibitors; Serotonin-norepinephrine reuptake inhibitors.

Publication types

  • Review

MeSH terms

  • Anti-Anxiety Agents / therapeutic use
  • Anxiety Disorders* / drug therapy
  • Anxiety Disorders* / therapy
  • Humans
  • Panic Disorder / drug therapy
  • Panic Disorder / therapy
  • Psychotherapy / methods
  • Selective Serotonin Reuptake Inhibitors* / therapeutic use
  • Serotonin and Noradrenaline Reuptake Inhibitors / therapeutic use

Substances

  • Selective Serotonin Reuptake Inhibitors
  • Anti-Anxiety Agents
  • Serotonin and Noradrenaline Reuptake Inhibitors