The Role of Lymphocytic Infiltrates in the Tumor Microenvironment as a Predictive Factor for the Response to Immunotherapy in Solid Tumors: A Single-Center Experience From Romania

Raluca Ioana Mihaila; Adelina Silvana Gheorghe; Daniela Luminita Zob; Dana Stanculeanu

doi:10.7759/cureus.74194

The Role of Lymphocytic Infiltrates in the Tumor Microenvironment as a Predictive Factor for the Response to Immunotherapy in Solid Tumors: A Single-Center Experience From Romania

Cureus. 2024 Nov 21;16(11):e74194. doi: 10.7759/cureus.74194. eCollection 2024 Nov.

Authors

Raluca Ioana Mihaila^{1

2}, Adelina Silvana Gheorghe², Daniela Luminita Zob³, Dana Stanculeanu⁴

Affiliations

¹ Oncology Department, University of Medicine and Pharmacy, Bucharest, ROU.
² Medical Oncology Department I, Institute of Oncology "Prof. Dr. Alexandru Trestioreanu", Bucharest, ROU.
³ Medical Oncology Department II, Institute of Oncology "Prof. Dr. Alexandru Trestioreanu", Bucharest, ROU.
⁴ Medical Oncology Department, Institute of Oncology "Prof. Dr. Alexandru Trestioreanu", Bucharest, ROU.

Abstract

The correlation between tumor-infiltrating lymphocytes (TILs) and immunotherapy responses is an evolving field with significant clinical implications. Immunotherapy has revolutionized antineoplastic therapies, offering promising results for patients diagnosed with solid tumors. Integrating biomarkers, refining imaging techniques, and developing non-invasive methods may enhance personalized medicine, optimizing treatment strategies while minimizing adverse effects. In our study, we conducted a retrospective analysis to assess the practicality of utilizing the predictive value of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment (TME) correlating the response to immunotherapy in patients with solid tumors, comprehensively navigating through currently available data. Continued research efforts and collaboration between scientists and clinicians are essential to unlock the full potential of these biomarkers and advance the field of immunotherapy in solid tumors.

Keywords: immunotherapy; oncology; personalized treatment; predictive biomarkers; research; solid tumors; tils; tumor microenvironment; tumor response; tumor-infiltrating lymphocytes.