Rapidly Progressive Idiopathic Pyoderma Gangrenosum in a Pediatric Patient Successfully Treated With Infliximab

Abstract

Pyoderma gangrenosum (PG) is a rare skin disorder with poorly understood pathophysiology. PG infrequently occurs in children, and approximately 4% of patients with PG are infants and children. First line therapy is topical and systemic corticosteroids, which typically yields rapid response. We report a case of rapidly progressive pediatric PG of unknown inciting cause that ultimately required multi-modal therapy with systemic and topical corticosteroids, high-dose infliximab, and colchicine.

Keywords: infliximab; neutrophilic dermatosis; pediatric pyoderma gangrenosum.