This report presents findings from the National Survey on Best Practices for COVID-19 Vaccination and Testing, part of the Best Practices for COVID-19 Testing and Vaccination Study sponsored by the Office of the Assistant Secretary for Planning and Evaluation (ASPE) and the Office of the Assistant Secretary for Health (OASH). Mathematica, ASPE, and OASH designed the survey to gather information from local organizations about their efforts to improve COVID-19 testing and vaccination in populations that are medically or socially at disproportionate risk for COVID-19 or related adverse outcomes.