Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary

Arch Toxicol. 2025 Apr;99(4):1605-1609. doi: 10.1007/s00204-025-03958-9. Epub 2025 Jan 17.

Abstract

Exposomics is a field that studies environmental exposures and their impact on human health. The MRM-IDA-EPI method, which combines targeted and untargeted mass spectrometry methods, is useful for identifying and quantifying biomarkers in various biological matrices. The method's accuracy and precision in forensic toxicological screening suggest potential applications for detecting low-level environmental exposures. It can help detect and understand environmental exposures, explain their metabolic processes, and assess their impact on human health more effectively.

Keywords: Biomonitoring; Exposome; Hybrid Targeted/Untargeted Screening; MRM-IDA-EPI Scan; QTRAP LC-MS/MS.

MeSH terms

  • Biomarkers / analysis
  • Environmental Exposure* / analysis
  • Exposome*
  • Forensic Toxicology / methods
  • Humans
  • Mass Spectrometry* / methods

Substances

  • Biomarkers