Like, share, and spike: Glioblastoma progenitors influence neuronal excitability at the glioma-neural interface

Christopher W Mount; Mario L Suvà

doi:10.1016/j.neuron.2024.12.021

Like, share, and spike: Glioblastoma progenitors influence neuronal excitability at the glioma-neural interface

Neuron. 2025 Jan 22;113(2):185-186. doi: 10.1016/j.neuron.2024.12.021.

Authors

Christopher W Mount¹, Mario L Suvà²

Affiliations

¹ Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: cmount@mgh.harvard.edu.
² Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: Suva.Mario@mgh.harvard.edu.

PMID: 39848227
DOI: 10.1016/j.neuron.2024.12.021

Abstract

Writing in Neuron, Zhang et al. identify a subpopulation of glioblastoma cells from patient tumor samples with progenitor-like features that expresses the potassium ion channel KCND2.¹ In mouse and organoid models, these cells enhance neural activity at the glioma-neural interface.

MeSH terms

Animals
Brain Neoplasms* / metabolism
Brain Neoplasms* / pathology
Brain Neoplasms* / physiopathology
Glioblastoma* / metabolism
Glioblastoma* / pathology
Glioblastoma* / physiopathology
Glioma* / pathology
Glioma* / physiopathology
Humans
Mice
Neoplastic Stem Cells*
Neurons* / physiology