Utility of Polygenic Risk Scores (PRSs) in Predicting Pancreatic Cancer: A Systematic Review and Meta-Analysis of Common-Variant and Mixed Scores with Insights into Rare Variant Analysis

Georgios Ioannis Verras; Zaed Z Hamady; Andrew Collins; William Tapper

doi:10.3390/cancers17020241

Utility of Polygenic Risk Scores (PRSs) in Predicting Pancreatic Cancer: A Systematic Review and Meta-Analysis of Common-Variant and Mixed Scores with Insights into Rare Variant Analysis

Cancers (Basel). 2025 Jan 13;17(2):241. doi: 10.3390/cancers17020241.

Authors

Georgios Ioannis Verras^{1

2}, Zaed Z Hamady^{1

2}, Andrew Collins¹, William Tapper¹

Affiliations

¹ School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
² Department of General Surgery, University Hospital Southampton, Southampton SO16 6YD, UK.

Abstract

Pancreatic adenocarcinoma is the most common histological subtype of pancreatic cancer, representing approximately 85% of all cases [...].

Keywords: clinical risk scores; genetic scores; pancreatic adenocarcinoma; pancreatic cancer; polygenic risk scores; risk prediction; risk stratification.

Publication types

Review

Grants and funding

PLANETS Cancer Charity