Receipt of Fluoroquinolone Prophylaxis is not Associated With Development of Vancomycin-Resistant Enterococcus Colonization During Pediatric Hematopoietic Cell Transplantation

J Pediatric Infect Dis Soc. 2025 Mar 12;14(3):piaf010. doi: 10.1093/jpids/piaf010.

Abstract

Fluoroquinolones are used to prevent bloodstream infections in pediatric hematopoietic cell transplant (HCT) recipients. We performed a retrospective cohort study in 799 pediatric HCT patients to evaluate the association between fluoroquinolone prophylaxis and VRE colonization. Propensity score analyses were performed. Fluoroquinolone prophylaxis was not associated with VRE colonization.

Keywords: children; fluoroquinolone; hematopoietic cell transplant; vancomycin-resistant Enterococcus.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents* / therapeutic use
  • Antibiotic Prophylaxis*
  • Child
  • Child, Preschool
  • Female
  • Fluoroquinolones* / therapeutic use
  • Gram-Positive Bacterial Infections* / microbiology
  • Gram-Positive Bacterial Infections* / prevention & control
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Infant
  • Male
  • Retrospective Studies
  • Vancomycin-Resistant Enterococci* / drug effects
  • Vancomycin-Resistant Enterococci* / isolation & purification

Substances

  • Fluoroquinolones
  • Anti-Bacterial Agents

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