The role of mesenchymal stem cells-derived from oral and teeth in regenerative and reconstructive medicine

Abstract

Defects and abnormalities of the skull, jaw, and face tissues due to various physiological problems such as speech, chewing, and swallowing disorders, cause illness and psychological effects with creation of significant public health challenges. Both autograft and allograft reconstruction methods, have different limitations, especially in the complete reconstruction of complex tissues such as sensory and periodontal tissues, which cannot be wholly relied on for treatment. Recently, mesenchymal stem cells (MSCs)-derived from oral and teeth have emerged as a promising alternative way in regenerative and reconstructive medicine. These types of stem cells with the high differentiation potential and self-renewal capabilities include dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDs), periodontal stem cells (PDLSCs) and gum-derived stem cells (GMSCs). These stem cells can be easily collected from accessible and numerous sources, such as extracted molars and milk teeth, with minimal invasiveness, playing pivotal roles in clinical application. This review explains the applications and therapeutic effects of the above-mentioned MSCs-derived from oral and dental tissues. Each of these stem cells, have unique characteristics and used for the treatment of specific abnormalities and defects. In this article, we aims to elucidate the indispensable and pivotal roles of MSCs-derived from the oral and teeth in addressing intractable and complex challenges in restorative and reconstructive medicine.

Keywords: Dental pulp stem cells (DPSCs); Mesenchymal stem cells (MSCs); Periodontal stem cells (PDLSCs); Regenerative medicine; Stem cells from human exfoliated deciduous teeth (SHEDs).