Do weight loss interventions challenge the obesity paradox in heart failure?

Salva R Yurista; Robert A Eder; W Scott Butsch; Ivan Luptak

doi:10.1016/j.tem.2025.01.006

Do weight loss interventions challenge the obesity paradox in heart failure?

Trends Endocrinol Metab. 2025 Apr;36(4):295-297. doi: 10.1016/j.tem.2025.01.006. Epub 2025 Feb 11.

Authors

Salva R Yurista¹, Robert A Eder², W Scott Butsch³, Ivan Luptak⁴

Affiliations

¹ Section of Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA. Electronic address: salva.yurista@bmc.org.
² New York Institute of Technology College of Osteopathic Medicine, New York, NY, USA.
³ Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH, USA.
⁴ Section of Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.

PMID: 39939208
DOI: 10.1016/j.tem.2025.01.006

Abstract

Cardiovascular disease (CVD) remains a significant global health concern, with obesity recognized as a prominent risk factor. The 'obesity paradox' (OP) suggests that obesity does not always lead to adverse outcomes, particularly in heart failure (HF). In this forum, we discuss the relevance of the OP in the current therapeutic landscape for cardiometabolic diseases.

Keywords: GLP-1RAs; bariatric surgery; heart failure; obesity paradox.

Publication types

Editorial

MeSH terms

Heart Failure* / metabolism
Humans
Obesity Paradox
Obesity* / complications
Obesity* / metabolism
Obesity* / therapy
Risk Factors
Weight Loss* / physiology