Tumor Necrosis Factor-Alpha Inhibitor Use and Malignancy Risk: A Systematic Review and Patient Level Meta-Analysis

Conor B Driscoll; Jordan M Rich; Dylan Isaacson; Joseph Nicolas; Yu Jiang; Xinlei Mi; Christopher Yang; Victoria Kocsuta; Regine Goh; Niti Patel; Eric Li; Mohammad Rashid Siddiqui; Travis Meyers; John S Witte; Linda Kachuri; Hui Zhang; Molly Beestrum; Philip Silberman; Edward M Schaeffer; Shilajit D Kundu

doi:10.3390/cancers17030390

Tumor Necrosis Factor-Alpha Inhibitor Use and Malignancy Risk: A Systematic Review and Patient Level Meta-Analysis

Cancers (Basel). 2025 Jan 24;17(3):390. doi: 10.3390/cancers17030390.

Authors

Conor B Driscoll¹, Jordan M Rich¹, Dylan Isaacson¹, Joseph Nicolas¹, Yu Jiang², Xinlei Mi³, Christopher Yang¹, Victoria Kocsuta¹, Regine Goh¹, Niti Patel⁴, Eric Li¹, Mohammad Rashid Siddiqui¹, Travis Meyers⁵, John S Witte^{2

6}, Linda Kachuri^{2

6}, Hui Zhang³, Molly Beestrum⁷, Philip Silberman⁸, Edward M Schaeffer¹, Shilajit D Kundu¹

Affiliations

¹ Department of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
² Department of Epidemiology and Population Health, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
³ Division of Biostatistics, Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Dr, Suite 1400, Chicago, IL 60611, USA.
⁴ Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Arkes Suite 2330, Chicago, IL 60611, USA.
⁵ Department of Epidemiology and Biostatistics, University of California at San Francisco, 550 16th St., Floor 2, San Francisco, CA 94143, USA.
⁶ Department of Biomedical Data Science, Stanford University, 1265 Welch Road MC5464MSOB West Wing, Third Floor, Stanford, CA 94305, USA.
⁷ Galter Health Sciences Library and Learning Center, Northwestern University, 303 E Chicago Ave #2-212, Chicago, IL 60611, USA.
⁸ Department of Information Technology, Northwestern University Feinberg School of Medicine, 710 N. Lake Shore Dr, Abbott Hall, 4th Floor, Chicago, IL 60611, USA.

Abstract

Over the last two decades, tumor necrosis factor-alpha inhibitors (TNF-Is) have become standard therapies for chronic inflammatory disorders, with an ongoing expansion of indications and off-label applications [...].

Keywords: TNF-alpha; adalimumab; cancer; certolizumab; etanercept; golimumab; infliximab; meta-analysis.

Publication types

Review

Grants and funding

N/A/Polsky Urologic Research Institute, Northwestern University