Minimally-invasive common-path OCT system for neurosurgery applications

Gary Evans; Jerome Gandar; Simon Thiele; David J Segar; Yoseline Rosales Cabara; Matthew Lapinski; Ivana Gantar; Thierry Campiche; Corinne Brana; Michalina J Gora; Jules Scholler

doi:10.1364/BOE.549160

Minimally-invasive common-path OCT system for neurosurgery applications

Biomed Opt Express. 2025 Jan 31;16(2):872-882. doi: 10.1364/BOE.549160. eCollection 2025 Feb 1.

Authors

Gary Evans^{1

2}, Jerome Gandar², Simon Thiele³, David J Segar^{4

5}, Yoseline Rosales Cabara², Matthew Lapinski^{1

2}, Ivana Gantar², Thierry Campiche², Corinne Brana², Michalina J Gora², Jules Scholler^{1

2}

Affiliations

¹ Clee Medical, Geneva, Switzerland.
² Wyss Center for Bio and NeuroEngineering, Geneva, Switzerland.
³ Printoptix GmbH, Nobelstr. 15, 70569 Stuttgart, Germany.
⁴ Department of Neurosurgery, Albert Einstein College of Medicine, New York, New York, USA.
⁵ Department of Radiology, University of California, San Francisco, San Francisco, CA, USA.

Abstract

We present a minimally-invasive common-path optical coherence tomography (OCT) system operating at 1310 nm with a novel forward viewing monolithic endoscope designed specifically for neurosurgical applications with real-time 3D imaging capabilities. This system's real-time tissue identification capability could enhance the accuracy of stereotactic surgeries, including deep brain stimulation and biopsy, while its ability to detect blood flow could significantly reduce the risk of hemorrhage. The system was successfully tested in vivo in a rabbit cohort.