Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis

Joshua Kotlyar; Richard D Granstein

doi:10.1016/j.bbih.2025.100958

Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis

Brain Behav Immun Health. 2025 Jan 30:44:100958. doi: 10.1016/j.bbih.2025.100958. eCollection 2025 Mar.

Authors

Joshua Kotlyar^{1

2}, Richard D Granstein¹

Affiliations

¹ Israel Englander Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, WGC9, New York, NY, 10021, USA.
² SUNY Downstate Health Sciences University College of Medicine, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA.

Abstract

The nervous system has a complex interplay with the immune system, especially at barrier sites such as the skin. This allows it to play a role in a variety of cutaneous inflammatory disorders such as psoriasis, exerting effects on various immune cells via effector molecules such as neuropeptides. In this review, we discuss the role of calcitonin gene-related peptide in modulating the immune system and inflammation, with a focus on psoriasis.

Keywords: Calcitonin gene-related peptide; Dendritic cells; Neurogenic inflammation; Nociceptors; Psoriasis; Skin immunity.

Publication types

Review