The Role of Prophylactic or Adjuvant Hyperthermic Intraperitoneal Therapy in Appendiceal and Colorectal Cancer Peritoneal Metastasis

Monique H Gandawidjaja; Belain Eyob; Abigail Chmiel; Oliver S Eng

doi:10.1016/j.soc.2024.12.001

The Role of Prophylactic or Adjuvant Hyperthermic Intraperitoneal Therapy in Appendiceal and Colorectal Cancer Peritoneal Metastasis

Surg Oncol Clin N Am. 2025 Apr;34(2):227-240. doi: 10.1016/j.soc.2024.12.001. Epub 2025 Jan 7.

Authors

Monique H Gandawidjaja¹, Belain Eyob¹, Abigail Chmiel², Oliver S Eng³

Affiliations

¹ Division of Surgical Oncology, Department of Surgery, University of California Irvine, 3800 Chapman Avenue, Suite 6200, Orange, CA 92868, USA.
² Department of Surgery, Washington University School of Medicine, MSC 8109-29-2300, 4590 Nash Way, Suite 2300, St. Louis, MO 63110, USA.
³ Division of Surgical Oncology, Department of Surgery, University of California Irvine, 3800 Chapman Avenue, Suite 6200, Orange, CA 92868, USA. Electronic address: oeng@hs.uci.edu.

PMID: 40015801
DOI: 10.1016/j.soc.2024.12.001

Abstract

Appendiceal neoplasms and colorectal cancer have a propensity to develop peritoneal metastases. Despite advancements in systemic therapy and surgical management, the development and management of peritoneal metastases remains a challenging problem. Utilization of adjuvant or prophylactic hyperthermic intraperitoneal chemotherapy has been described, with varying quality of data and reported outcomes. The utilization of prophylactic or adjuvant hyperthermic intraperitoneal chemotherapy in patients with appendiceal neoplasms and colorectal cancer remains an active area of exploration.

Keywords: Adjuvant; Appendiceal neoplasm; Colorectal cancer; Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy; Prophylactic.

Publication types

Review

MeSH terms

Appendiceal Neoplasms* / pathology
Appendiceal Neoplasms* / therapy
Chemotherapy, Adjuvant
Colorectal Neoplasms* / pathology
Colorectal Neoplasms* / therapy
Combined Modality Therapy
Humans
Hyperthermia, Induced*
Hyperthermic Intraperitoneal Chemotherapy* / methods
Peritoneal Neoplasms* / prevention & control
Peritoneal Neoplasms* / secondary
Peritoneal Neoplasms* / therapy