Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers

Cancer Discov. 2025 Mar 3;15(3):461-480. doi: 10.1158/2159-8290.CD-24-1326.

Abstract

Here, we explore the impact of three decades of BRCA1 research on the lives of mutation carriers and propose strategies to improve the prevention and treatment of BRCA1-associated cancer.

MeSH terms

  • BRCA1 Protein* / genetics
  • Breast Neoplasms* / genetics
  • Female
  • Genetic Predisposition to Disease
  • Heterozygote
  • Humans
  • Mutation*

Substances

  • BRCA1 Protein
  • BRCA1 protein, human