Optimal Medical Therapy in Peripheral Artery Disease

Abstract

Peripheral artery disease (PAD) is a highly prevalent subset of cardiovascular disease associated with significant limb-related and concomitant atherosclerotic complications, resulting in high morbidity and mortality. Consequently, appropriate identification and timely initiation of guideline-directed medical therapy is crucial. Despite its widespread prevalence, PAD remains underdiagnosed and undertreated, posing a substantial public health challenge. This review delves into the evidence-based nonpharmacological and pharmacologic treatment strategies for PAD, underscoring the necessity of a multidisciplinary approach.

Keywords: Antiplatelet therapy; Atherosclerosis; Guideline-directed medical therapy; Peripheral artery disease; Peripheral vascular disease; Supervised exercise therapy.