2024 ASHG presidential address: Incomplete penetrance and variable expressivity: Old concepts, new urgency

Bruce D Gelb

doi:10.1016/j.ajhg.2025.01.010

2024 ASHG presidential address: Incomplete penetrance and variable expressivity: Old concepts, new urgency

Am J Hum Genet. 2025 Mar 6;112(3):461-466. doi: 10.1016/j.ajhg.2025.01.010.

Author

Bruce D Gelb¹

Affiliation

¹ Icahn School of Medicine at Mount Sinai, Mindich Child Health and Development Institute and the Departments of Pediatrics and Genetics and Genomic Sciences, New York, NY 10029, USA. Electronic address: bruce.gelb@mssm.edu.

PMID: 40054435
PMCID: PMC11993877 (available on 2025-09-06)
DOI: 10.1016/j.ajhg.2025.01.010

Abstract

This article is based on the address given by the author at the 2024 meeting of The American Society of Human Genetics (ASHG) in Denver, CO. A video of the original address can be found at the ASHG website.

Publication types

Address

MeSH terms

Genetics, Medical*
Human Genetics*
Humans
Penetrance*
Societies, Medical