A multidisciplinary protocol for reducing excessive and maintaining a healthy body weight in the personalized management of chronic diseases in children and adults

PLoS One. 2025 Mar 13;20(3):e0306400. doi: 10.1371/journal.pone.0306400. eCollection 2025.

Abstract

Despite regularly used treatment asthma in both children and adults is not fully controlled. This is more prominent in certain disease subtypes, such as obese asthma. The vast complexity of asthma phenotypes and often overlapping endotypes emphasizes the need for implementing the concept of precision medicine in disease management. In order to address these concerns, an innovative and personalized programme for reducing excessive and maintaining a healthy body weight will be developed by experts from pharmaceutical and food industry (Belupo Inc. and Podravka Inc., Croatia) as well as clinical experts (Srebrnjak Children`s Hospital, Croatia). The programme will involve meals replacement (standard and innovative formulas), dietary program and nutritional counseling, physical activity and other individually tailored measures according specific disease phenotypes and underlying pathophysiological mechanisms in each participant. The outcomes of this study should contribute to better control of the underlying condition, reduction of the frequency and severity of symptoms and, consequently, in the improvement of the participant's overall quality of life.

MeSH terms

  • Adolescent
  • Adult
  • Asthma* / therapy
  • Body Weight*
  • Child
  • Chronic Disease / therapy
  • Exercise
  • Female
  • Humans
  • Male
  • Obesity* / therapy
  • Precision Medicine* / methods
  • Quality of Life

Grants and funding

This study is funded by the European Regional Development Fund, the Operational Program for Competitiveness and Cohesion, calls for capacity building for research, development and innovation (KK.01.1.1.07.0075).