Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach

Rajal B Shah; Gladell P Paner; Liang Cheng; Angelo M De Marzo; Cristina Magi-Galluzzi; Murali Varma; Ming Zhou; Ali Amin; Mahul B Amin; Manju Aron; Isabela W Cunha; Jonathan I Epstein; Samson W Fine; Aiman Haider; Kenneth A Iczkowski; James G Kench; Lakshmi Priya Kunju; Sambit K Mohanty; Rodolfo Montironi; George J Netto; Chin-Chen Pan; Priya Rao; John R Srigley; Guido Sauter; Puay Hoon Tan; Toyonori Tsuzuki; Theodorus H van der Kwast; Geert J van Leenders; Glen Kristiansen

doi:10.1016/j.eururo.2025.02.029

Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach

Eur Urol. 2025 Jul;88(1):8-10. doi: 10.1016/j.eururo.2025.02.029. Epub 2025 Mar 17.

Authors

Rajal B Shah¹, Gladell P Paner², Liang Cheng³, Angelo M De Marzo⁴, Cristina Magi-Galluzzi⁵, Murali Varma⁶, Ming Zhou⁷, Ali Amin³, Mahul B Amin⁸, Manju Aron⁹, Isabela W Cunha¹⁰, Jonathan I Epstein¹¹, Samson W Fine¹², Aiman Haider¹³, Kenneth A Iczkowski¹⁴, James G Kench¹⁵, Lakshmi Priya Kunju¹⁶, Sambit K Mohanty¹⁷, Rodolfo Montironi¹⁸, George J Netto¹⁹, Chin-Chen Pan²⁰, Priya Rao²¹, John R Srigley²², Guido Sauter²³, Puay Hoon Tan²⁴, Toyonori Tsuzuki²⁵, Theodorus H van der Kwast²⁶, Geert J van Leenders²⁷, Glen Kristiansen²⁸

Affiliations

¹ Division of Anatomic Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: rajal.shah@utsouthwestern.edu.
² Departments of Pathology and Surgery (Urology), University of Chicago, Chicago, IL, USA.
³ Department of Pathology, Alpert Medical School, Brown University, Providence, RI, USA.
⁴ Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
⁵ Department of Pathology, University of Alabama at Birmingham, Birmingham. AL USA.
⁶ Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.
⁷ Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA.
⁸ Department of Pathology and Laboratory Medicine, University of Tennessee Health Science System, Memphis, TN, USA; Department of Urology, USC Keck School of Medicine, Los Angeles, CA, USA.
⁹ Department of Urology, USC Keck School of Medicine, Los Angeles, CA, USA; Department of Pathology, USC Keck School of Medicine, Los Angeles, CA, USA.
¹⁰ D'Or Institute for Research and Education and Department of Pathology, Rede D'Or/Sao Luiz Hospital, Sao Paulo, Brazil.
¹¹ Integrate Medical Professionals Pathology, Garden City, NY, USA.
¹² Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹³ Department of Pathology, University College London Hospital, London, UK.
¹⁴ Department of Pathology and Laboratory Medicine, University of California-Davis Health, Sacramento, CA, USA.
¹⁵ Department of Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital, Camperdown, Australia.
¹⁶ Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
¹⁷ Department of Pathology, CORE Diagnostics, Gurgaon, India.
¹⁸ Department of Pathology and Molecular Medicine and Cell Therapy Foundation, Polytechnic University of the Marche, Ancona, Italy.
¹⁹ Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA.
²⁰ Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan.
²¹ Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
²² Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
²³ Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²⁴ Department of Anatomical Pathology, Luma Medical Center, Singapore.
²⁵ Department of Surgical Pathology, Aichi Medical University, Nagakute, Japan.
²⁶ Laboratory Medicine Program, University Health Network, University of Toronto, Toronto, Canada.
²⁷ Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
²⁸ Institute of Pathology, University Hospital Bonn, Bonn, Germany. Electronic address: glen.kristiansen@ukbonn.de.

PMID: 40102113
DOI: 10.1016/j.eururo.2025.02.029

Abstract

Detection of indolent prostate cancer in contemporary practice is an issue that can result in overtreatment for patients and a financial burden for health care systems. Solutions to this problem require a coordinated multidisciplinary approach involving clinicians, radiologists, and pathologists.

Publication types

Editorial

MeSH terms

Humans
Interdisciplinary Communication
Male
Patient Care Team*
Prostatic Neoplasms* / classification
Prostatic Neoplasms* / diagnosis
Prostatic Neoplasms* / pathology
Prostatic Neoplasms* / therapy
Societies, Medical
Urology