Pioneering the Future of Oral Healthcare: Bioprinting and Its Transformative Clinical Potential in Dentistry

Cureus. 2025 Feb 15;17(2):e79030. doi: 10.7759/cureus.79030. eCollection 2025 Feb.

Abstract

Bioprinting is revolutionizing the field of dentistry by enabling the fabrication of complex dental tissues using advanced techniques like inkjet, extrusion-based, and laser-assisted bioprinting. These methods allow for the precise placement of cells and materials to regenerate dental pulp, periodontal tissues, alveolar bone, and temporomandibular joint structures. Hydrogels, composite bioinks, and cell-laden bioinks play a crucial role in scaffold formation and improving cell viability. Preclinical models have demonstrated the potential of bioprinting for tissue regeneration and dental implants, with early clinical trials showing promising results. However, challenges remain, including scalability, material selection, immune response, and regulatory approval. Future advancements in multi-material bioprinting, real-time monitoring, and personalized treatment approaches will expand clinical applications of bioprinting, driving innovation in oral healthcare and improving patient outcomes.

Keywords: bioinks; bioprinting; innovative dentistry; regeneration; tissue engineering.

Publication types

  • Review