Objectives: This study examined the associations between cumulative adult physical activity and vasomotor symptoms (hot flushes and night sweats) of menopause among women aged 40-48.
Methods: Data from 6569 women in the 1973-78 cohort of the Australian Longitudinal Study on Women's Health (ALSHW) were analysed in 2024. Physical activity data were collected every three years from age 22-28 to 43-48. Participants were classified into low, moderate, and high levels of cumulative physical activity based on their reported activity across the surveys. The main outcome was the occurrence of vasomotor symptoms, specifically hot flushes and night sweats, reported by participants at age 40-48.
Results: At age 40-48, 21.4% reported hot flushes (26.6% low, 20.7% moderate, 20% high activity), and 25.5% reported night sweats (27.7% low, 24.9% moderate, 25.0% high activity). Women with moderate levels of cumulative physical activity from their early 30s to early 40s had 20% lower odds of experiencing hot flushes than those with low activity levels (OR: 0.80, 95% CI: 0.67-0.95). This association remained statistically significant after adjusting for sociodemographic factors (OR: 0.83, 95% CI: 0.69-0.99) but was no longer significant after further adjustment for health-related factors, including alcohol consumption, body mass index, menopausal status, self-rated health, anxiety, and depression. No significant associations were found between cumulative physical activity and vasomotor symptoms for other life stages.
Conclusions: Although overall cumulative physical activity levels were not associated with vasomotor symptoms, moderate cumulative physical activity levels from the early 30s to early 40s were associated with lower odds of experiencing hot flushes.
Keywords: Hot flash; Life course; Lifespan; Night sweat; Physical activity; Vasomotor symptom.
Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.