Infectious Complications in Patients Treated with T-cell Engagers as Cancer Immunotherapies, A Descriptive Study from the REISAMIC Registry

Thomas Hueso; Justin Cagnat; Kaïssa Ouali; Mathilde Haberstich; Benoît Henry; Alina Danu; Camille Bigenwald; Mansouria Merad; Sabine Messayke; Ariane Laparra; Madona Sakkal; Cristina Smolenschi; Antoine Hollebecque; Anas Gazzah; Capucine Baldini; Rastislav Bahleda; Benjamin Besse; Charlotte Rigaud; Véronique Minard-Colin; Vincent Ribrag; Salim Laghouati; Elisabeth Chachaty; Fabrice Barlesi; Aurélien Marabelle; Olivier Lambotte; Christophe Massard; Jean-Marie Michot

doi:10.1093/cid/ciaf164

Infectious Complications in Patients Treated with T-cell Engagers as Cancer Immunotherapies, A Descriptive Study from the REISAMIC Registry

Clin Infect Dis. 2025 Apr 1:ciaf164. doi: 10.1093/cid/ciaf164. Online ahead of print.

Authors

Thomas Hueso^{1

2}, Justin Cagnat¹, Kaïssa Ouali¹, Mathilde Haberstich¹, Benoît Henry³, Alina Danu², Camille Bigenwald², Mansouria Merad⁴, Sabine Messayke⁵, Ariane Laparra¹, Madona Sakkal¹, Cristina Smolenschi¹, Antoine Hollebecque¹, Anas Gazzah¹, Capucine Baldini¹, Rastislav Bahleda¹, Benjamin Besse^{6

7}, Charlotte Rigaud⁸, Véronique Minard-Colin^{8

7}, Vincent Ribrag^{1

2}, Salim Laghouati⁵, Elisabeth Chachaty⁹, Fabrice Barlesi^{6

7}, Aurélien Marabelle^{1

7}, Olivier Lambotte^{10

7}, Christophe Massard^{1

7}, Jean-Marie Michot^{1

2}

Affiliations

¹ Early Drug Development Department, Gustave Roussy, F-94805 Villejuif, France.
² Department of Clinical Hematology, Gustave Roussy, F-94805 Villejuif, France.
³ Department of Infectious Disease, Kremlin Bicêtre Hospital (AP-HP), F-94275 Kremlin-Bicêtre, France.
⁴ Department of Medical Emergency, Gustave Roussy, F-94805 Villejuif, France.
⁵ Pharmacovigilance Unit, Clinical Research Direction, Gustave Roussy, F-94805 Villejuif, France.
⁶ Department of Medical Oncology, Gustave Roussy, F-94805 Villejuif, France.
⁷ Paris-Saclay University.
⁸ Department of Pediatric Cancer, Gustave Roussy, F-94805 Villejuif, France.
⁹ Department of Microbiology, Gustave Roussy, F-94805 Villejuif, France.
¹⁰ Department of Internal Medicine and Clinical Immunology, Kremlin-Bicêtre Hospital (AP-HP), UMR1184 IMVA-HB, IDMIT, CEA, INSERM, le Kremlin-Bicêtre, France.

PMID: 40165410
DOI: 10.1093/cid/ciaf164

Abstract

We investigated infectious complications and the associated risk factors in 181 patients undergoing T-cell engagers for malignancies. Infections were primarily observed in patients with hematological diseases or heavily pre-treated. Mortality due to infectious complications was 2.8%. Concomitant medications with corticosteroids or tocilizumab did not significantly impact the incidence of infections.

Keywords: BCMA; Bispecific antibodies; CD20; DLL3; Infections; T-cell engagers.

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