Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection

Liang En Wee; Jue Tao Lim; Enoch Xueheng Loy; Calvin J Chiew; E Shyong Tai; Su Chi Lim; Yong Mong Bee; Sock Hwee Tan; Charmaine Qing Fei Chan; Wai Leng Chow; James Wei Luen Yip; Khung Keong Yeo; Benjamin Ong; David Chien Boon Lye; Mark Yan Yee Chan; Derek J Hausenloy; Kelvin Bryan Tan

doi:10.1001/jamanetworkopen.2025.2959

Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection

JAMA Netw Open. 2025 Apr 1;8(4):e252959. doi: 10.1001/jamanetworkopen.2025.2959.

Authors

Liang En Wee^{1

2

3}, Jue Tao Lim^{1

4}, Enoch Xueheng Loy¹, Calvin J Chiew^{1

5}, E Shyong Tai^{6

7

8}, Su Chi Lim^{4

7

9

10}, Yong Mong Bee^{2

11}, Sock Hwee Tan⁶, Charmaine Qing Fei Chan⁵, Wai Leng Chow^{5

7}, James Wei Luen Yip^{6

12}, Khung Keong Yeo^{2

13}, Benjamin Ong^{5

6}, David Chien Boon Lye^{1

4

6

14}, Mark Yan Yee Chan^{6

12}, Derek J Hausenloy^{2

6

15

16}, Kelvin Bryan Tan^{1

2

4

5

7}

Affiliations

¹ National Centre for Infectious Diseases, Singapore.
² Duke-NUS Medical School, National University of Singapore, Singapore.
³ Department of Infectious Diseases, Singapore General Hospital, Singapore.
⁴ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
⁵ Ministry of Health, Singapore.
⁶ Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁷ Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
⁸ Department of Medicine, Yong Loo Lin School of Medicine, Singapore.
⁹ Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
¹⁰ Diabetes Centre, Admiralty Medical Centre, Singapore.
¹¹ Department of Endocrinology, Singapore General Hospital, Singapore.
¹² Department of Cardiology, National University Heart Centre, Singapore.
¹³ Department of Cardiology, National Heart Centre Singapore, Singapore.
¹⁴ Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
¹⁵ National Heart Research Institute Singapore, National Heart Centre, Singapore.
¹⁶ The Hatter Cardiovascular Institute, University College London, London, United Kingdom.

No abstract available

Plain language summary

This cohort study estimates the risk of new-onset type 2 diabetes after Delta or Omicron variant SARS-CoV-2 infection among vaccinated adults in Singapore.