Mycoplasma genitalium is characterized by a small genome and a lack of a cell wall, contributing to its unique biology. It is associated with reproductive tract infections, including non-gonococcal urethritis and pelvic inflammatory disease. It is nearly as common as chlamydia in most studies from high-income countries. The emergence of antimicrobial resistance in M. genitalium raises concern about the long-term efficacy of current therapeutic strategies. Understanding its genomic intricacies and pathogenic mechanisms is crucial for developing targeted interventions to address the growing public health impact of this elusive microbe.
Keywords: fluoroquinolones; macrolide resistance; non-gonococcal urethritis.