Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Anders Kämpe; Sanna Gudmundsson; Colum P Walsh; Kerstin Lindblad-Toh; Åsa Johansson; Anna Clareborn; Adam Ameur; Anders Edsjö; Thoas Fioretos; Hans Ehrencrona; Daniel Eriksson; Tove Fall; Paul W Franks; Ulf Gyllensten; Margareta Haag; Anna Hagwall; Maria Johansson Soller; Janne Lehtiö; Yi Lu; Patrik K E Magnusson; Erik Melén; Beatrice Melin; Karl Michaëlsson; Ann Nordgren; Jessica Nordlund; Lao H Saal; Jochen M Schwenk; Per Sikora; Johan Sundström; Fulya Taylan; Bethany Van Guelpen; Mia Wadelius; Anna Wedell; Valtteri Wirta; Päivi Östling; Bo Jacobsson; Tobias Sjöblom; Bengt Persson; Richard Rosenquist; Anna Lindstrand; Tuuli Lappalainen

doi:10.1038/s41591-025-03631-9

Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Nat Med. 2025 Jun;31(6):1730-1732. doi: 10.1038/s41591-025-03631-9.

Authors

Anders Kämpe^{1

2}, Sanna Gudmundsson^{3

4}, Colum P Walsh^{5

6}, Kerstin Lindblad-Toh^{7

8

9}, Åsa Johansson^{8

10}, Anna Clareborn¹⁰, Adam Ameur^{8

10}, Anders Edsjö^{11

12}, Thoas Fioretos^{11

13

14}, Hans Ehrencrona^{11

13}, Daniel Eriksson¹⁰, Tove Fall^{8

15}, Paul W Franks^{16

17}, Ulf Gyllensten¹⁰, Margareta Haag¹⁸, Anna Hagwall¹⁹, Maria Johansson Soller¹, Janne Lehtiö²⁰, Yi Lu²¹, Patrik K E Magnusson²¹, Erik Melén²², Beatrice Melin²³, Karl Michaëlsson²⁴, Ann Nordgren^{1

2

25

26}, Jessica Nordlund^{8

15}, Lao H Saal²⁷, Jochen M Schwenk²⁸, Per Sikora^{25

29}, Johan Sundström^{15

30}, Fulya Taylan^{1

2}, Bethany Van Guelpen^{23

31}, Mia Wadelius^{8

15}, Anna Wedell^{1

32}, Valtteri Wirta^{2

3

33}, Päivi Östling^{8

20}, Bo Jacobsson^{34

35

36}, Tobias Sjöblom^{8

10}, Bengt Persson¹⁹, Richard Rosenquist^{37

38}, Anna Lindstrand^{39

40}, Tuuli Lappalainen^{41

42}

Affiliations

¹ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
² Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden.
³ Department of Gene Technology, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
⁴ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁵ Clinical Genomics, SciLifeLab, Linköping, Sweden.
⁶ Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
⁷ Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
⁸ SciLifeLab, Uppsala University, Uppsala, Sweden.
⁹ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁰ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
¹¹ Department of Clinical Genetics, Pathology and Molecular Diagnostics, Skåne University Hospital, Lund, Sweden.
¹² Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
¹³ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
¹⁴ Clinical Genomics, SciLifeLab, Lund, Sweden.
¹⁵ Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
¹⁶ Department of Clinical Sciences, Lund University, Helsingborg, Sweden.
¹⁷ Precision Health University Research Institute, Queen Mary University of London, London, UK.
¹⁸ The Swedish Network Against Cancer, Stockholm, Sweden.
¹⁹ Department of Cell and Molecular Biology, NBIS, SciLifeLab, Uppsala University, Uppsala, Sweden.
²⁰ Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
²¹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
²² Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
²³ Department of Diagnostics and Intervention, Oncology, Umeå University, Umeå, Sweden.
²⁴ Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
²⁵ Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁶ Department of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
²⁷ Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden.
²⁸ Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
²⁹ Bioinformatics and Data Centre, University of Gothenburg, Gothenburg, Sweden.
³⁰ The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
³¹ Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.
³² Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
³³ Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
³⁴ Department of Obstetrics and Gynecology, University of Gothenburg, Gothenburg, Sweden.
³⁵ Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Western Health Care Region, Gothenburg, Sweden.
³⁶ Department of Genetics and Bioinformatics, Division of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway.
³⁷ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. richard.rosenquist@ki.se.
³⁸ Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden. richard.rosenquist@ki.se.
³⁹ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. anna.lindstrand@ki.se.
⁴⁰ Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden. anna.lindstrand@ki.se.
⁴¹ Department of Gene Technology, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden. tuuli.lappalainen@scilifelab.se.
⁴² New York Genome Center, New York, NY, USA. tuuli.lappalainen@scilifelab.se.

PMID: 40186080
DOI: 10.1038/s41591-025-03631-9

No abstract available

Publication types

Letter