C-reactive protein and digestive pathologies: A narrative review for daily clinical use

Reza Kianmanesh; Koceila Lamine Amroun; Rami Rhaiem; Amir Hossein Davarpanah Jazi; Hashem Moazenzadeh; Linda Rached; Perrine Zimmermann; Adrien Durame; Yohann Renard; Ambroise Ravenet; Olivier Bouche; Sophie Deguelte

doi:10.4103/jrms.jrms_537_23

C-reactive protein and digestive pathologies: A narrative review for daily clinical use

J Res Med Sci. 2025 Feb 28:30:10. doi: 10.4103/jrms.jrms_537_23. eCollection 2025.

Authors

Reza Kianmanesh^{1

2}, Koceila Lamine Amroun^{1

2

3}, Rami Rhaiem^{1

2}, Amir Hossein Davarpanah Jazi⁴, Hashem Moazenzadeh², Linda Rached², Perrine Zimmermann^{1

2}, Adrien Durame^{1

2}, Yohann Renard^{1

2}, Ambroise Ravenet^{1

2}, Olivier Bouche^{1

5}, Sophie Deguelte^{1

2

3}

Affiliations

¹ Reims Medical Faculty, Champagne Ardenne University, Ardenne, France.
² Department of General, Digestive and Endocrine Surgery, Christian Cabrol Hospital University, Reims, France.
³ Department of Clinical Research, Aging and Fragility Unit UR 3797, Hospital University, Reims, France.
⁴ Department of Minimally Invasive and Bariatric Surgery, Hazrate Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.
⁵ Department of Digestive Oncology, CHU Robert Debré, Reims, France.

Abstract

The aim of this narrative review is to familiarize clinicians, especially digestive surgeons, to adequately use of serum C-reactive protein as a reliable noninvasive biomarker in diverse practical clinical situations. We hope that the review will help clinicians for their decision-making when facing various digestive diseases including operative and nonoperative pathologies such as anastomotic leakage, pancreatitis, emergency situation, and digestive cancer management and prognosis.

Keywords: C-reactive protein; Cancer prognosis; digestive surgery; postoperative complications.

Publication types

Review

Grants and funding

Nil.