Introduction: Giant Serpentine Aneurysms (GSA) are a rare subgroup of complex intracranial vascular anomalies characterized by unusually large and convoluted structures within cerebral arteries. This systematic review examines the historical context, clinical presentations, diagnostic methodologies, and evolving treatments specific to GSAs. Its goal is to advance patient care strategies and outcomes within this intricate neurovascular domain.
Methods: Research encompassing patients diagnosed with GSAs was gathered from PubMed, Google Scholar, and Web of Science. Only comprehensive human studies published in English were considered, using search terms like giant serpentine aneurysm, thrombosed aneurysm, bypass, and angiography. Data regarding patient age, gender, symptoms upon presentation, treatments, recovery duration, and outcomes were systematically documented.
Result: This analysis of 83 patients with GSA found the middle cerebral artery as the most common site (39.8%). Headaches (54.2%) and visual issues (9.8%) prevailed as symptoms. Seizures correlated with more post-op problems. Females encountered more neurological issues post-surgery (46.4%). Treatment methods varied by location but didn't significantly affect age or hospital stay length.
Conclusion: Early recognition and intervention are crucial for mitigating neurological deficits and improving patient prognosis in GSAs. Expanded research and awareness are needed for definitive diagnostic protocols and treatment guidelines.
Keywords: angiography; bypass; giant serpentine aneurysm; thrombosed aneurysm.
Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.