Loss of WNT2B Results in Epithelial Defects and Predisposes to Gastrointestinal Dysplasia in Humans

Leslie Lori; Valentin Neuranter; Corinne Lebreton; Jérémy Berthelet; Marianna Parlato; Christina Michail; Anis Khiat; Dominique Berrebi; Julie Bruneau; Benoit Terris; Georgia Malamut; Sylvain Hanein; Yohann Schmitt; Céline Banal; Fernando Rodrigues Lima; Emilie Azouguene; Frank Ruemmele; Cecile Talbotec; Cecile Lambe; Nadine Cerf-Bensussan; Fabienne Charbit-Henrion

doi:10.1016/j.jcmgh.2025.101514

Loss of WNT2B Results in Epithelial Defects and Predisposes to Gastrointestinal Dysplasia in Humans

Cell Mol Gastroenterol Hepatol. 2025 Apr 11:101514. doi: 10.1016/j.jcmgh.2025.101514. Online ahead of print.

Authors

Leslie Lori¹, Valentin Neuranter¹, Corinne Lebreton¹, Jérémy Berthelet², Marianna Parlato¹, Christina Michail², Anis Khiat¹, Dominique Berrebi³, Julie Bruneau³, Benoit Terris⁴, Georgia Malamut⁵, Sylvain Hanein⁶, Yohann Schmitt⁷, Céline Banal⁸, Fernando Rodrigues Lima⁹, Emilie Azouguene¹⁰, Frank Ruemmele¹¹, Cecile Talbotec¹², Cecile Lambe¹¹, Nadine Cerf-Bensussan¹, Fabienne Charbit-Henrion¹³

Affiliations

¹ Université Paris-Cité, Institut Imagine, Laboratory of Intestinal Immunity, INSERM U1163, Paris, France.
² Université Paris Cité, CNRS, Epigenetics and Cell Fate, Paris, France.
³ Department of Pathology, AP-HP. Centre-Université Paris Cité, Hôpital Necker-Enfants Malades, Paris, France.
⁴ Department of Pathology, AP-HP. Centre-Université Paris Cité, Hôpital Cochin, Paris, France.
⁵ Université Paris-Cité, Institut Imagine, Laboratory of Intestinal Immunity, INSERM U1163, Paris, France; Department of Gastroenterology, AP-HP. Centre-Université Paris Cité, Hôpital Cochin, Paris, France.
⁶ Bioinformatic Platform, Institute of Genetic Diseases, INSERM UMR1163, Imagine, Université Paris-Cité and Structure Fédérative de Recherche Necker, Paris, France.
⁷ Genomics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163 et INSERM US24/CNRS UAR3633, Paris Cite University, Paris, France.
⁸ Université Paris-Cité, iPSC Core Facility, Institut Imagine, INSERM U1163, Paris, France.
⁹ Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.
¹⁰ Department of Genomic Medecine of Rare Diseases, AP-HP. Centre-Université Paris Cité, Hôpital Necker-Enfants Malades, Paris, France.
¹¹ Université Paris-Cité, Institut Imagine, Laboratory of Intestinal Immunity, INSERM U1163, Paris, France; Service de Gastro-entérologie et Nutrition Pédiatrique, AP-HP. Centre-Université Paris Cité, Hôpital Necker-Enfants Malades, Paris, France.
¹² Service de Gastro-entérologie et Nutrition Pédiatrique, AP-HP. Centre-Université Paris Cité, Hôpital Necker-Enfants Malades, Paris, France.
¹³ Université Paris-Cité, Institut Imagine, Laboratory of Intestinal Immunity, INSERM U1163, Paris, France; Department of Genomic Medecine of Rare Diseases, AP-HP. Centre-Université Paris Cité, Hôpital Necker-Enfants Malades, Paris, France. Electronic address: fabienne.charbit-henrion@aphp.fr.

PMID: 40221090
DOI: 10.1016/j.jcmgh.2025.101514

No abstract available