A dominant-negative IFNGR1 variant reveals broad immune cell sequestering of IFN-γ

Samantha Chan; Mai B Margetts; Longfei Wang; Jack Godsell; Josh Chatelier; Belinda Liu; Charlotte A Slade; Andrew Brett; Kasha P Singh; Vanessa L Bryant; Lauren J Howson

doi:10.1172/JCI186799

A dominant-negative IFNGR1 variant reveals broad immune cell sequestering of IFN-γ

J Clin Invest. 2025 Apr 15;135(8):e186799. doi: 10.1172/JCI186799.

Authors

Samantha Chan^{1

2

3

4

5}, Mai B Margetts¹, Longfei Wang^{2

6}, Jack Godsell^{3

5}, Josh Chatelier^{3

4}, Belinda Liu⁷, Charlotte A Slade^{1

2

3}, Andrew Brett⁸, Kasha P Singh^{9

10}, Vanessa L Bryant^{1

2

3}, Lauren J Howson^{1

2

3}

Affiliations

¹ Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
² Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
³ Department of Clinical Immunology and Allergy, Royal Melbourne Hospital, Parkville, Victoria, Australia.
⁴ Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.
⁵ Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, Australia.
⁶ Genetics and Gene Regulation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
⁷ Department of Respiratory Medicine and Sleep Disorders, Royal Melbourne Hospital, Parkville, Victoria, Australia.
⁸ Department of Gastroenterology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
⁹ Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
¹⁰ Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia.

No abstract available

Keywords: Cellular immune response; Genetic diseases; Genetics; Immunology.